At least one person, an 18-year-old woman, is dead after a a suspected drunk-driver ploughed into pedestrians in New York's Times Square.
22 people are injured including four people who remain in a critical condition, New York Police Department (NYPD) confirmed.
The dead woman's 13-year-old sister is among the wounded.
Horrific images have begun to emerge of people laying on the ground, including the girl who appears lifeless with her face covered by a blanket.
The speeding vehicle, driving in the wrong direction, smashed into pedestrians.
One injured pedestrian told Reuters the driver’s actions appeared to be “intentional”.
GETTY • EPA • REUTERS
At least 20 people have been injured after a car hit pedestrians in Times Square
The car, a red Honda Accord, crashed into a pole and came to rest at 45th Street and Broadway.
It then burst into flames as firefighters rushed to put it out and prevent more people being injured.
Those struck by the dark coloured car are being placed on stretchers, wrapped in blood-stained blankets, in the busy tourist spot.
The New York Fire Department has confirmed there are at least 22 people injured.
FBI officers have been called in to investigate.
Speeding car ploughs into pedestrians in Times Square
Thu, May 18, 2017
A driver has driven a vehicle into crowds in New York's Times Square, leaving at least one person dead
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Emergency services tend to the injured
NYPD sealed off the area with buildings around the busy tourist site put on lockdown and people moved away from the scene.
The driver, a former member of the armed forces, has been arrested.
Police Commissioner James O’Neill confirmed the driver was New Yorker Richard Rojas, aged 26.
Rojas, a US Navy veteran with a history of driving while intoxicated, was arrested and is being tested for alcohol.
Footage emerged of the dark haired man, appearing to be in his 20s, being detained by police.
A woman is surrounded on the ground in Times Square as she is cared for by others
Terror in New York as car hits pedestrians: Emergency services on scene
New York in terror as victims lay injured on the ground
He was surrounded by officers and marched across the road, appearing to be injured.
Officers then forced him into the back of the car.
The NYPD said it is not believed, at this point, the crash was terror related.
New York mayor Bill de Blasio said: "Based on the information we have at this moment, there is no indication that this was an act of terrorism.
"This is a tough day for New York City, but I want to thank our first responders who got here so quickly.
"We feel deeply for those injured and particularly for the family of the young woman who was lost. Our prayers are with all of them."
The New York Fire Department said that four people were in a critical condition, three were seriously hurt and 15 were "less serious".
President Donald Trump was "made aware of the situation in Times Square and will continue to receive updates", his spokesman Sean Spicer said.
Terror in New York: Pedestrians stop to help those hit by the car
David Shuster Tweeted from his nearby office: “Vehicle just drove on sidewalk Times Square on 7th between 42nd/43rd, People down. Police on scene.
“Buildings in lock down, including ours.”
Another witness said people were “screaming and running”.
A witness told Sky News: “I was on my way to a business meeting and I came up on the gruesome scene – victims on the sidewalk and the street.
“I saw head injuries and blood and a victim not moving then I knew it was much more serious.”
He claimed the NYPD were on the scene quickly and the area was swiftly evacuated.
New York terror as police rush to understand how car ended up hitting pedestrians
Witnesses have described their own narrow misses with the vehicle.
Josh Duboff, an employee at the adjacent Thomson Reuters headquarters said: ”People were being hit and rolling off the car.”
The crash took place near the headquarters of the Reuters news agency, 3 Times Square.
Building foreman Rodney Muir said he heard what sounded like a big bang and crunching metal. He said he looked out and saw what appeared to be a body lying on the street in front of the building.
Cheryl Howard and her daughter were out shopping when the car sped down the sidewalk.
Her daughter said: ”I’m so freaked out!They mowed everyone down."
Mrs Howard had blood dripping down her right arm and a swollen bruise above her left eye. One injured woman nearby had a large open wound on her leg.
Car pictured in Times Square after hitting pedestrians in Times Square
A US Government official said there is “no evidence” the Times Square crash is linked to terror.
Despite reports the man is known to officers, the Government said his identity is currently “unknown”.
New York Governor Andrew Cuomo was called to the scene and briefed by NYPD officers.
Witnesses have said people were 'screaming and running' away from Times Square
13 total patients currently reported at scene of motor vehicle accident in Times Square pic.twitter.com/ySwtL6ZLoc
— FDNY (@FDNY) May 18, 2017
Social media reports began to emerge of a second crash in Staten Island.
Police insisted the traffic collision is completely unrelated to the crash in Times Square.
More than 300,000 people, many of them tourists, pass through Times Square every day, according to its official website.