In comments set to needle ECB president Mario Draghi, Angela Merkel's finance chief has urged the central bank to change policies hurting German savers and households.
Mr Scháuble waded out of his remit to pile pressure on the central bank to roll back its controversial mammoth money printing programme in 2017 and raise interest rates, in interviews published this week.
The move is set to again unravel relations between the two, which hit a low last year amid public bickering over monetary policies.
Mr Scháuble told the Sueddeutsche Zeitung newspaper: "The European Central Bank will have the tough task of getting out of the ultra-expansionary monetary policy.
"It would presumably be right if the ECB dared to exit this year."
Previous interventions by the politician last year prompted Mr Draghi to declare: "We have a mandate to pursue price stability for the whole of the eurozone not only for Germany.
"We obey the law, not the politicians, because we are independent as stated by the law."
So-called Quantitative Easing and negative interest rates implemented by the ECB have helped stoke inflation in the eurozone, with the cost of living jumping to its highest level in four years last month.
Mr Scháuble appears alarmed over forecasts that inflation could reach three per cent in Germany this year, which could further fuel a backlash against Ms Merkel's ruling party ahead of national elections.
In separate comments, the German finance minister this week told the The European magazine: "A normalisation of the inflation rate is also desirable so that we gradually get out of the 'unusual monetary policy'."
He added: "I would much prefer it if interest rates were not so low."
Mr Scháuble has previously said low interest rates were hurting German savers and helping to provide support for anti-euro political parties.
The ECB is hoping that its policies will kick-start growth in struggling economies, such as France, Italy and Spain.
But the finance minister appears to be exasperated that Germany is being held back by policies targeted at different member states.
He told the Sueddeutsche Zeitung: "The problem is the weakness of the other countries, not Germany's strength."
The vast gap in performance of eurozone economies is an ongoing dilemma for the ECB.
And the rise in inflation is set to make the central bank's policy decisions even trickier when it next meets.
In December the ECB announced it would carry on injecting billions of cash into the eurozone until the end of 2017 - the money-printing programme had been due to finish in March.
But minutes from the meeting showed the Governing Council was split over the whether to extend the Quantitative Easing and opponents openly voiced their disagreement.
It's likely one of the members against the measure was Germany's central bank president Jens Weidmann, who has publicly expressed concern over the ECB policies.