Jane Garvey, a Woman’s Hour host on Radio 4, told the First Minister that the SNP were going to lose seats in the June 8 vote.
Nicola Sturgeon rejected the host’s comments arguing the SNP are doing everything to win every seat in Scotland.
The First Minister also suggested in the BBC interview that the SNP would prop up the Labour Party to stop the Conservatives from getting into power.
She said: “We are going into this election significantly ahead in the polls of our nearest rivals.
The BBC host told Nicola Sturgeon the SNP would lose seats in the June 8 vote
“We are on course, again I stress, I do not take a single vote for granted, but we are on course to win this election in Scotland.
“I think that is a pretty strong position to be in. Of course, if you are in Government if you have been in Government like the SNP has been for 10 years.
“Then there will be people who disagree with you on a number of things.
“For a party that has been in government for that length of time to have that poll position that we have got is a positive not a negative.”
The host then told the First Minister that the SNP would not be able to hold onto all the seats they gained in the 2015 election where they won 56 of 59 seats in Scotland.
Garvey said: “Nevertheless you are in a kind of strange position because the SNP won 56 of 59 seats last time round.
You are going to lose seats this time
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“You are going to lose seats this time.”
The First Minister attempted to laugh off the remark as she said: “You are not seriously expecting me to concede that before an election”.
Garvey then made her point a second time insisting the SNP could not make any more progress in Scotland.
She said: “I will put it to you, Nicola Sturgeon, there is a very strong possibility, you will lose seats not gain them”.
Ms Sturgeon would not accept the SNP would lose seats in the election arguing that they were attempting to win every constituency in Scotland.
“Look we are fighting every constituency to win it,” she replied.
“We had an absolutely exceptional election result in 2015, two years ago, I recognise that, but we are fighting every seat to win and we are fighting hard.”
The TV election debate – in pictures Wed, May 31, 2017
The televised debate saw Jeremy Corbyn, Amber Rudd, Paul Nuttall, Caroline Lucas, Angus Robertson, Tim Farron and Leanne Wood go toe-to-toe
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The politicians taking part in the debate
The First Minister also appeared to accept Theresa May’s statement that “now is not the time” for another independence referendum claiming it would be held at “the end of the [Brexit] process.
Ms Sturgeon insisted that she did want a good Brexit deal for the UK in negotiation with the EU, and suggested she would go into coalition with Mr Corbyn to oust the Conservatives.
She said: “I said this in 2015, if the parliamentary arithmetic post the election supported this, I would want the SNP to be part of a progressive alternative to a Tory government.
“I don’t favour formal coalitions. I’m talking something that would be much more on an issue by issue basis.
“To make sure that we had a government that invested in public services not cut public services.”