The Daily Politics host spelt out a brutally simple point for Brussels, suggesting they can’t afford to 'pick a fight' with the UK as the Prime Minister triggers Article 50.
Neil said the EU are fighting on all corners and wouldn’t want to begin a battle with Theresa May during their negotiations.
He said: “Let’s just stand back because the geopolitics of this doesn’t get enough coverage. Let’s look at Europe’s position for a moment.
“To the east, it faces a group of autocrats and dictators who are threatening its borders in various ways from hard and soft power.
Andrew Neil questioned EU's motives to start a negotiation war with Britain
Europe, from three sides, has real problems in its hands, why would you then pick a fight with Britain
“To the west, it faces a hostile American administration for the first time ever, an administration who doesn’t seem to care about the EU, whether it lives or dies.
“To the south, it faces the continued outflow and carnage of the Arab Spring, and the huge refugee problem that it has brought.
“So when you look at Europe from three sides and the real problems in its hands, why would you then pick a fight with Britain?”
Chris Leslie replied: “Well you pick the right way of characterising it. I was in Germany last week talking to politicians in Berlin, they put Brexit in this same basket with all these other threats and challenges.
“It’s just for them, one of many, which I think the mood I picked up is that they are trying to glue each other together, and, in doing so, that might mean proving that you are better off staying inside the European Union.
“That I worry about because I think they will have to illustrate that we are losing out.”
The host added that the EU may conclude that they need Britain’s help with their issues, which would lead to a good deal for the UK.
He added: “I just wonder, why would you really want a fight?”
Shortly after receiving the Prime Minister’s letter, signalling her intention to guide Britain out of the failing bloc, Donald Tusk announced Brussels was already “missing” Britain as he said his farewells to the nation.
Brexit day LIVE: images from around the country as Britain invokes Article 50 Wed, March 29, 2017
The country reacts as Theresa May officially invokes Article 50, and begins the process of Britain leaving the European Union
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Prime Minister Theresa May announces in the House of Commons that she has triggered Article 50, starting a two-year countdown to the UK leaving the EU
During a press conference in Brussels, the President of the European Commission admitted it was a “sad day” in the history of the organisation.
He said: “There is no reason to pretend that this is a happy day, neither in Brussels nor in London.
“After all most Europeans, including almost half the British voters, wish that we would stay together not drift apart.”
The EU Council chief, who spoke in a sombre tone, said that he and Commission chief Jean-Claude Juncker were now determined to protect the interests of the other 27 member states.