Who will be the next Doctor Who? Will James Norton or Ben Whishaw replace Peter Capaldi?
He made the announcement whilst discussing what fans can expect from the latest season on Jo Whiley's BBC Radio 2 show.
"I suppose the big thing for me is that it will be my last. It will be the end for me," explained the 58-year-old.
Moments after the shock announcement, speculation immediately began of who would take the coveted role of the famous Time Lord.
William Hill have set fans' tongues wagging by naming Ben Whishaw as the favourite at 6/1.
The 36-year-old certainly has an impressive track record having most recently starred as Q in Bond films Skyfall and Spectre.
Whishaw recently won the best leading actor TV Bafta for his role in Richard II and was nominated again in 2016 for his lead role in BBC's London Spy.
The Bedfordshire-born actor has also starred alongside Capaldi in the 2014 film, Paddington.
Closely following Whishaw is joint favourite, James Norton.
Paddy Power and Betfair both placed the 31-year-old at the top of their lists to take the lead role when Capaldi leaves.
Having already starred in an episode of Doctor Who in 2013, Norton previously said he "would happily go back" to the show.
The actor is best known for his roles in Happy Valley, Granchester and War and Peace.
Peter Capaldi with new companion Pearl Mackie
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Who will be the next Doctor Who?
Tue, January 31, 2017
Doctor Who: Who will replace Peter Capaldi as the next doctor? Here are the bookies favourites.
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Who will replace Peter Capaldi as the next Doctor?
I would happily go back to Doctor Who
However, it seems the writing is on the wall as another Spectre actor is within arms reach of the TARDIS.
Rory Kinnear, who played Tanner in recent Bond films, is among the favourites once again for the top job.
Kinnear would follow in the steps of former Doctors, David Tennant and Christopher Eccleston in having performed in Shakespearean plays.
However, when asked if he would be replacing Matt Smith in 2013, the actor insister he had never even watched Doctor Who.
Hot on the tails of the Bond alumni is also Richard Ayoade at 8/1.
The 39-year-old is best known for his role as loveable geek Maurice Moss on Channel 4's The IT Crowd.
Aside from his comedy role, Ayoade has made a name for himself as a director for his 2010 rom-com Submarine as well as voicing The Snowman in the BBC's Danger Mouse revival.
The popular actor was also the president of Cambridge University's famed theatrical group, the Footlights, whose former presidents included Hugh Laurie and Sue Perkins.
Rory Kinnear and Richard Ayoade are also in the running
Lara Pulver and Miranda Hart are among speculation
There is also significant speculation that this time around fans could finally see the female Doctor discussed by head-writer Steven Moffat when Matt Smith quit.
Lara Pulver and Miranda Hart are leading the female rumours with odds of 10/1 and 8/1 respectively.
Pulver, 36, has previously encountered a large fandom when she took the iconic role of Irene Adler in BBC's Sherlock.
Comedienne, Hart, was most recently known for her more serious role on BBC's Call the Midwife but recently quit the show last year.
Doctor Who will return to BBC One later this year.