Mr Trump’s fans will be cheering as the Republican billionaire replaces Barack Obama and moves into the White House.
But there are also concerns over what Mr Trump’s presidency could mean for the world as he enters America’s highest office.
Mr Trump will take the oath of office during an inauguration ceremony filled with pomp, pageantry and music on Friday.
Ahead of his inauguration, here is a look at the schedule for the day and how you can watch the events unfold here in the UK.
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Donald Trump will take the oath of office during his inauguration on Friday
Donald Trump will become US President on Friday
What time is Donald Trump’s inauguration?
Mr Trump will be sworn in as US President during a ceremony at noon local time (5pm GMT) at the US Capitol Building in Washington.
What happens on Friday January January 20?
Mr Trump's family will attend a religious service at St John’s Episcopal Church, near the President’s guesthouse Blair House, at 8.30am local time (1.30pm GMT).
The billionaire will meet Mr Obama at the White House at 9.30am (2.30pm GMT) and they will travel down Pennsylvania Avenue to the Capitol together.
The swearing-in ceremony will begin with opening remarks at 11.30am (4.30pm GMT), followed by the oath and Mr Trumps inaugural speech.
Singer Jackie Evancho and The Mormon Tabernacle Choir are set to perform at the inauguration ceremony.
After the inauguration, there will be an inaugural parade from the Capitol Building, down Pennsylvania Avenue, to the White House.
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The New York City Rockettes are among the groups and bands that will take part in the parade.
In the evening there will be two inaugural balls where Mr Trump is expected to speak and dance with the other guests.
What will happen on Thursday January 19?
The celebrations begin with a wreath-laying ceremony to commemorate America’s war dead at the Arlington National Cemetery at 3pm local time (8pm GMT).
Rock band 3 Doors Down and country star Toby Keith are among the performers at the Make America Great Again! event at the the Lincoln Memorial at 4pm local time (9pm GMT).
Mr Trump, the new Vice President Mike Pence and their families thank donors at a dinner at Washington’s Union Station at 7.30pm local time (12.30am GMT)
What will happen on Saturday January 21?
There will be a traditional prayer service at the Washington National Cathedral at 10am local time (3pm GMT).
The Women’s March on Washington will begin with a rally at Capitol Hill at 10am local time (3pm GMT).
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How to watch Donald Trump’s inauguration in the UK
BBC One will begin its live coverage of the inauguration at 4pm GMT with Katty Kay reporting from the Capitol.
Sky News will cover Mr Trump’s inauguration from 3pm GMT, while Sky Atlantic coverage begins at 4pm. You can watch Sky News online here.
People in the UK, America and around the world can also live stream Mr Trump’s speech on the Right Side website.