Head coach Rob Howley has named both players to start against at the Principality Stadium, despite wing North and fly-half Biggar failing to recover fully from thigh and rib problems suffered in the opening-round 33-7 victory over Italy in Rome.
It represents an injury gamble by Wales, who will continue to assess two of their key backs in the next 48 hours. Howley is prepared to wait until as close as possible to the 4.50pm start before deciding whether the duo are available to start.
North, who scored a superb try against Italy despite suffering a nasty haematoma in his thigh early on, is the bigger of two injury worries after only limited involvement in training this week.
“George hasn’t done too much and Dan’s done a couple of sessions,” said Howley. “Those two will be given every opportunity to prove their fitness – they’re important players.
Wales head coach Rob Howley named both players to start against Wales
George North will face a late fitness test before facing England
“It’s a big game and both players want to be part of the team, as you’d expect.
“We’ve prepared as best as we can and we’ve got some extremely motivated players looking forward to the challenge England will bring.”
Howley has made just two changes from the side which beat Italy as he bids to end England’s 15-match winning run.
Props Rob Evans and Tomas Francis come into the starting XV after impressing off the bench at the Stadio Olimpico, with Nicky Smith and Samson Lee relegated to the bench. Bath No8 Taulupe Faletau is also among the substitutes after recovering from a knee problem which has prevented him from playing this year.
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Should North fail his late fitness test, Alex Cuthbert – who scored two tries when Wales destroyed Grand Slam-chasing England in Cardiff four years ago – is likely to come in on the wing while Sam Davies remains back-up to Biggar.
Third-choice fly-half Owen Williams has been released to Leicester, but Wales retain the option to recall the Gloucester-bound should Biggar pull up short.
“We’ve trained as best we can and are looking forward to facing one of the best sides, if not the best side, in the northern hemisphere,” Howley added.
“Before Italy, we tried to prepare a little bit about England as well. They have gone 15 games unbeaten, and they’ve got huge confidence and self-belief. You admire their strength in depth.
“They got across the line against France. In the first games at the weekend there is always a rustiness, and we saw elements of that, but no doubt they will be ready for this game.”
Wales have lost their last three Six Nations meetings with England and are firm underdogs. But with Sam Warburton, Justin Tipuric and Ross Moriarty in their back row and Faletau to come off the bench, Howley will hope his team will have an advantage in that area at least.
England have picked an inexperienced loose forward trio of Maro Itoje, Jack Clifford and Nathan Hughes, and Howley added: “The quality and experience in that back row will have a significant impact on the game. Toby hasn’t played for a long time, but it hasn’t looked like that in training.
“Wales and England games at Principality Stadium are always tight affairs. It’s a game the players, supporters and coaches look forward to.”