The MEP for South East England said he was convinced current Ukip leader Mr Nuttall will be victorious in kick-starting the next stage in the party’s history.
Speaking on Sunday Politics, Mr Farage said: “I’ve always been told, never make predictions. But I like making predictions, I think Paul will win Stoke.”
Put to him that the constituency was one of Ukip’s best chances in the country and that it is referred to as “the capital of Brexit”, Mr Farage said the win would send a powerful message.
Nigel Farage is confident over Paul Nuttall by-election result
I like making predictions, I think Paul will win Stoke
He said: “If he doesn’t it will be tough, if he doesn’t we’ll still have our four million loyalists.
"If he does, then we can actually see that Labour are beatable in their heartlands and I think Ukip will be off to the second very big stage of its history.”
Labour’s candidate for the Stoke central by-election previously claimed on Twitter that Brexit was a “massive pile of s**t”.
Paul Nuttall confident of political earthquake
Councillor Gareth Snell tweeted the comments ahead of the election, which was triggered by former Labour MP Tristram Hunt’s decision to step down and take a job at the Victoria and Albert Museum.
Heidi Alexander claimed she had the support of 18 backbenchers who said they would not support plans to leave the single market.
Mr Farage slammed the former shadow health secretary on Twitter.
The leading Brexiteer said: “The 19 Labour MPs opposing Article 50 are enemies of democracy & should be made to pay the price at the ballot box.”
Nigel Farage in pictures
Thu, December 15, 2016
Nigel Farage is a British politician who has been the leader of the UK Independence Party since October 2016.
1 of 48
British politician Nigel Farage arrives at Trump Tower on December 15, 2016 in New York City. President-elect Donald Trump and his transition team are in the process of filling cabinet and other high level positions for the new administration.
Sources have claimed up to 80 Labour MPs could defy leader Jeremy Corbyn’s three-line-whip on voting for Article 50 in March.
This is more than one in three of the 229 Labour MPs in Parliament.
More than 3,500 Constituency Labour Party members have signed an open letter to the leader, saying the move "goes against our very soul".
But Mr Corbyn has finally given a blanket approval of Article 50, insisting that no matter what happens, Brexit will go through.