The socialist politician, who resigned from embattled Francois Hollande's government just last year, has issued a video message in a bid to woo talent from across the Atlantic.
In a direct message, where he speaks in English, Mr Macron, 39, reaches out to his overseas audience despite battling the election in his own country.
Mr Macron is dicing with disaster as he focus on international affairs while Paris is burning
I do know how your new president now has decided to jeopardise your budget
Mr Macron, who posted his message of hope on Facebook, is a presidential favourite and is going up against the surging Marine Le Pen, who leads the right wing Front National (FN).
He said: "Hello to everyone.
"This is a message for American researchers, entrepreneurs, engineers, working on climate change.
"Last Saturday I invited you to come to France and join European and French researchers to work on climate change here, because here you are welcome.
Macron told children to be quiet when he visited New York City
"I do know how your new president now has decided to jeopardise your budget, you initiatives as he is extremely skeptical about climate change.
"I have no doubt about climate change and how committed we have to be regarding this issue so I have two messages.
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"The very first one for the French and European researchers we will preserve our budgets, we will reinforce our investment, our public and private investment in order to do more and accelerate our initiative in order deliver in line with COP21.
Trump met Canadian PM Justin Trudeau at the White House after he publicly criticised him
"Please come to France. You are welcome, it's your nation, we like innovation.
"We want innovative people, we want people working on climate change, energy, renewables and new technologies.
"France is your nation.”
Also in the running are The Socialist Party's (PS) Benoît Hamon, cronyism row plagued François Fillon of the The Republicans (LR) and Jean-Luc Mélenchon of Unsubmissive France, (La France insoumise).
Macron posed for selfies at a French taxpayer funded NYC party as people giggled in the background
Appearing to focus on foreign affairs rather than domestic issues Mr Macron sent his plea to Americans while riots broke out in the streets of Paris.
Five towns in a northern suburb have seen violence not witnessed since 2005 but EU supporter Mr Macron appears to be hopeful that outbreaks of terror on the streets will not put people off.
En Marche candidate Mr Macron, who is married to his high school teacher, visited Mr Trump's home town of New York city six weeks before the president was inaugurated.
Front National presidential hopeful Marine Le Pen visited Trump Tower
Mr Macron posed for selfies with students after speaking at New York University, Columbia University, the New York French American Charter School as well as hosting a party at the French consulate.
And he took time to visit the 9/11 memorial with a representative from New York city's Government and Community affairs but notably did not meet Mr Trump.
Mr Macron may have trouble attracting US entrepreneurs to France due to the US's FATCA policy which allows government personnel to locate ex-pats to find out if they owe tax or penalties.
Macron's attention is on America while his city is burning around him
It was introduced by the Obama administration and has helped the Unites States track down and work out how much their overseas citizens are worth.
Mr Macron could also face difficulty attracting climate change pioneers to France as Trump has indicated that he is to encourage firms to bring business back to America offering them tax breaks.
In 2015 it was estimated that the climate change market was worth $1.5 trillion globally.
Shocking photos depict riots in Paris after police 'sodomizes' youth Tue, February 7, 2017
Chaos in Paris as video emerges of ‘police raping black youth with truncheon’. The man was rushed to hospital and was reportedly 'traumatised' with a 'severe wound'. Clashes between young protesters and police forces sparked for the second evening and left several cars burnt and five people in custody in Aulnay-sous-Bois.
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Cars were torched
The industry’ grew at between 17 and 24 per cent annually from 2005-2008 according to the Climate Change Business Journal.
Climate change is unlikely to be high on the President's agenda as he battles with immigration and defence issues.
Last week it was revealed the Mr Macron's former colleague now French finance minister Michel Sapin failed in his bid to attract Wall Street banks to relocate to Paris from London.
Mr Sapin has been trying to bolster France's prominence in the world's financial markets ahead of Britain's exit from the EU.
However, during a trip to the US to discuss the potential of relocation last October he was forced to use a translator which did not play out well for his intentions.
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