Kane has missed Tottenham’s last three Premier League games with an ankle injury he picked up against Millwall in the FA Cup last month.
But the England international has returned to Spurs’ bench for today’s visit of Stoke, with Vincent Janssen starting up front in place of Moussa Sissoko.
Hugo Lloris also returns between the sticks as Kieran Trippier comes in for Kyle Walker at right-back.
While Watford have made four changes at White Hart Lane.
Adrian Mariappa, Daryl Janmaat, Isaac Success and Stefano Okaka come in for Miguel Britos (banned), Sebastian Prodl (injured) and benched pair Etienne Capoue and Troy Deeney.
Tottenham: Lloris (c), Trippier, Alderweireld, Vertonghen, Davies, Dier, Dembele, Son, Eriksen, Dele, Janssen
Subs: Lopez, Walker, Wimmer, Nkoudou, Sissoko, Wanyama, Kane
Watford: Gomes (c); Mariappa, Cathcart, Holebas; Janmaat, Cleverley, Doucouré, Amrabat; Niang, Okaka, Success
Subs: Pantilimon, Kabasele, Eleftheriou, Mason, Zúñiga, Capoue, Deeney