The 59-year-old actress is starring as the formidable Dr Lydia Fonseca, head doctor at a public hospital in India, in the six-part series.
The plot follows Ruby, a young British-Asian doctor (played by Amrita Acharia), who gives up her job in Nottingham to work in the Indian state of Kerala.
There she meets no-nonsense Dr Fonseca whose philosophy is to never turn a single patient away.
In the first episode, viewers will see Amanda's character enjoy "mutually beneficial arrangement" with a bar owner (Neil Morrissey) after a long day of making life or death decisions at the medical institute.
The Good Karma Hospital: Amanda Redman stars with Neil Morrissey in new ITV drama
The Good Karma Hospital: The series follows a junior doctor who moves to India
We both rose to it!
At a special screening for the Good Karma Hospital attended by Express.co.uk, Amanda was asked how she found jumping into bed with Neil.
"It was very different but we both rose to it!" she laughed.
Writer Dan Sefton, who is also an A&E doctor, wrote Dr Fonseca especially for the New Tricks star.
Speaking about her character, she said: “She was wonderful. She just leapt off the page for me with her one liners. She’s quite complex and passionate.”
The Good Karma Hospital: Amanda plays the hospital's head doctor Lydia Fonseca
Amanda Redman in pictures
Wed, February 1, 2017
Amanda Redman, star of ITV's new drama The Good Karma Hospital, in pictures.
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English actress Amanda Redman in pictures
The series was filmed in nearby Sri Lanka because it was monsoon season in India.
Spending 12 weeks away shooting the series, Amanda has since fallen in love with the island nation.
"I loved it. It’s such a beautiful place,” she enthused.
The Good Karma Hospital will start tonight at 9pm on ITV.