The ardent Remainer was the only Conservative MP to try and block the Government’s Brexit Bill on Wednesday night.
Despite the former chancellor’s intervention, the legislation that gives Theresa May permission to begin formal negotiations with the EU was passed by a majority of 384.
However, after the result of the historic vote was announced, Mr Clarke vowed to continue his fight against the will of the British people.
Ken Clarke warned the "battle has only just started"
The battle has only just started
Ken Clarke MP
Speaking on Sky News at the end of the two-day debate, the Remain MP said: “The battle has only just started. We live in a very unreal, silly world since the rather startling result of the referendum.”
“There are plenty of members of the house who agree with me about the disastrous nature of the decision that has been taken – but they had all signed up to the referendum with nobody guessing that it might go that way.”
He accused the Conservative Government of not having a credible plan in place to divorce Britain from the EU ahead of the forthcoming negotiations.
The ardent Remainer was the only Conservative MP to vote against the Bill
The Prime Minister previously promised to begin official Brexit talks by no later than the end of March – much to the despair of the Tory grandee.
“I think Mr Farage was as surprised as Mr Cameron when the result came through and we are on a voyage of discovery now with a sketchy outlined negotiating position but with nobody with the first idea with what the real negations are going to be like,” he thundered.
Mr Clarke was one of 114 MPs who voted against the European Union (Notification of Withdrawl) Bill.
He previously compared visions of a post-Brexit future to a “wonderland-type” fantasy, saying “apparently you follow the rabbit down the hole and you emerge in a wonderland where suddenly countries around the world are queuing up to give us trading advantages."
The third reading of the Bill is expected to take place next Wednesday, giving MPs the final chance to say whether they approve it before it is passed to the House of Lords.
This is when the main battles over the legislation are expected to come as politicians look to add amendments to the second reading.
Labour amendments could include moves to ensure MPs have the first vote on any proposed exit deal, while the Liberal Democrats aim to ensure a second referendum.
MPs voted overwhelmingly to give Theresa May permission to begin Brexit talks
A spokesman for Jeremy Corbyn said: “Labour MPs voted more than three to one in favour of triggering Article 50.
"Now the battle of the week ahead is to shape Brexit negotiations to put jobs, living standards and accountability centre stage.
"Labour's amendments are the real agenda.”