United, who are 2-0 up following the first-leg, bring back Matteo Darmian, Marcos Rojo, Michael Carrick, Jesse Lingard and Marcus Rashford to the starting XI.
Luke Shaw is on the bench while Anthony Martial is not in the squad.
For Hull new signing Lazar Markovic is on the bench.
Manchester United boss Jose Mourinho has named a strong side to face Hull
Hull: Marshall, Tymon, Maguire, Dawson, Meyler, Huddlestone, Clucas, Maloney, Niasse, Diomande, Bowen.
Subs: Kuciak, Elabdellaoui, Robertson, Weir, Evandro, Markovic, Hernandez.
Man United stars forced to drive down a farm track to get to training
Thu, January 26, 2017
Manchester United players were forced to take a detour down a tiny farm track in order to reach their Carrington training base on Wednesday
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Manchester United stars were forced to take a detour to training on Wednesday
Man United: De Gea, Darmian, Smaliing, Jones, Rojo, Carrick, Herrera, Lingard, Pogba, Rashford, Ibrahimovic.
Subs: Romero, Fosu-Mensah, Shaw, Fellaini, Mata, Mkhitaryan, Rooney.