Eric Bailly and Daley Blind come into the defence, while Paul Pogba and Marouane Fellaini start in midfield.
Juan Mata and Zlatan Ibrahimovic also start.
Wayne Rooney is still missing.
Manchester United boss Jose Mourinho has made changes for tonight's clash with St Etienne
St Etienne: Ruffier, Theophile-Catherine, Pajot, Saivet, Veretout, Pogba, Hamouma, Monnet-Paquet, Perrin, Malcuit, Beric.
Subs:Moulin, Lacroix, Roux, Selnaes, Lemoine, Intima, Pierre-Gabriel.
Man United jet off to France ahead of Saint-Etienne clash
Tue, February 21, 2017
Express Sport brings you all the best snaps as Manchester United jet off for their Europa League clash with Saint-Etienne
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Manchester United have jetted off to France to face Saint-Etienne
Man United: Romero, Young, Bailly, Smalling, Blind, Carrick, Pogba, Fellaini, Mkhitaryan, Mata, Ibrahimovic.
Subs: De Gea, Valencia, Rojo, Schweinsteiger, Lingard, Martial, Rashford.