Tony Clubb will require surgery on a medical condition
Former London prop Clubb, 29, is managing a medical condition that will require surgery and several months on the sidelines while he recovers.
Homegrown half-back Shorrocks, 21, played against Widnes in Super League earlier this season but has since picked up a serious knee injury and will definitely not play again this year.
Wigan general manager Kris Radlinski said: “Tony has a medical condition, unrelated to any injury, that he has been managing for many years. Having struggled with it recently, doctors have advised that he will need a routine operation.
Anthony Gelling faces a one-match ban for a dangerous challenge on Mason Caton-Brown
“Tony is expected to make a full recovery but will need time to recover from the surgery. It’s difficult to put a timeframe on a return but we are hopeful that he might play again later this season.
“Jake picked up an injury in the Widnes game and recovered well from that only to suffer a severe knee injury in non-contact training.
“We are unable to put a timeframe on the injury however we don’t expect him to play again this season. It’s a tough pill to swallow for both Tony and Jake.”
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Who will make up the Lions’ starting XV, based on odds from William Hill?
Wigan centre Anthony Gelling is facing a one-match ban after being charged by the RFL with a dangerous challenge on Mason Caton-Brown during Monday’s win at Wakefield.
The offence carries a maximum two-match suspension but Gelling has the option of taking an early-guilty plea to ensure a lesser punishment.
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Warrington duo Daryl Clark and Declan Patton have been charged with striking and tripping respectively during their home victory over Huddersfield on Monday. Both players have the option of taking an early-guilty plea.