Macheda is widely regarded as a Manchester United cult hero.
Despite scoring just five goals for the club, his first means he will always be remembered fondly by those at Old Trafford.
The forward scored a stunning late winner when United beat Aston Villa 3-2 back in 2009.
It set the Red Devils on course to win the title ahead of fierce rivals Liverpool.
Many expected Macheda to kick on and become the club's striker for years to come but his potential was never fulfilled.
Federico Macheda celebrates scoring against Aston Villa in 2009
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Manchester Untied players made several young fans' dreams come true when they took part in the club's foundation dream day, meeting supporters with serious and life-limiting illnesses
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Manchester United stars meet young fans during the club's foundation dream day
And the 25-year-old, now at Italian club Novara Calcio, has admitted that his decision to defy Ferguson and snub a loan move within the Premier League ultimately ruined his career.
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"I had a few runs of games but I needed to be playing every week," he told ESPN.
"Fergie wanted me to go on loan; I could see that was sensible. Many Premier League clubs came in for me including Everton and Sunderland.
"But I wanted to play in Italy, in Serie A. Fergie did not agree and said I should play in England, where he could keep an eye on me. He said he didn't have the same power in Italy.
"I insisted on Italy and that was the worst mistake of my life.
Federico Macheda has admitted he was wrong to defy Sir Alex Ferguson
"I should have listened to Fergie. Sampdoria had been in the Champions League playoff that season; they had a good team.
"I was going to replace Antonio Cassano and play up front with [Giampaolo] Pazzini. I started well and scored straight away against Udinese, then started against Milan, Napoli, Juventus, Roma.
"But then they sold Pazzini to Inter Milan. I was only 19; I couldn't take the responsibility that he had.
"We went down the table and I started to get strong criticism, with people saying: 'He's come from Man United; who does he think he is?' For the first time in my life my confidence dropped. I began to ask myself: 'Am I good enough?' And I started to get injured."