Wolfgang Schäuble, who is the German finance minister, said that the Brexit decision has united Europe rather than divided the continent.
Speaking to Euronews at the European Business Summit, Mr Schäuble said the UK's decision showed the rest of the bloc just how disastrous leaving the EU would be.
When pressed on the impact of the British decision to leave the EU, Merkel's right-hand man called Brexit a one-off made by the "strange British people" who will live to regret it.
During his appearance at the Brussels conference, Mr Schäuble also blamed the eurozone financial crisis on the US before laying out plans to bring European project closer together.
Wolfgang Schäuble, who is the German finance minister, said that Brexit has united the EU
Wolfgang Schäuble mocked the Brexit decision as a massive mistake
The European finance minister said: "Europe is not doing so bad. Do not underestimate European economies and societies.
"Maybe the Brexit decision has been a wake-up call – for the eurosceptics.
"Even Madame Le Pen – between the first and second round – declared that she would not leave the monetary union. People see that the EU integration is not so bad.
"Europe is realising that perhaps being in the EU means they have a much better life than outside the bloc."
He added: "The British people will learn that the Brexit decision is a mistake.
"Europe will be a beacon to the rest of the world. We can showcase our sustainable growth and our free societies.
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"The British can be protectionist but Europe is fighting against this. Open markets, competition are much better."
Merkel's right-hand man called Brexit a one-off made by the "strange British people"
Schäuble mocked the British people for their "strange decision" to leave the EU
The British people will learn that the Brexit decision is a mistake
Mr Schäuble mocked the British people for their "strange decision" to leave the EU, as he said everyone in the bloc but them could see that the European project had brought success to each country.
His remarks come as the German economy continues to go from strength to strength, despite the uncertainty surrounding Brexit.
Clemens Fuest, president of the Munich-based Ifo think-tank, said the mood in Germany was "euphoric".
He said: “What we are witnessing is a strengthening recovery in Europe, particularly in the core.
"With political risks now ebbing away, economics has quickly taken over."
The region’s economic expansion outpaced both UK and US growth in the first quarter of 2017.