Jose Mourinho is hoping Manchester United secure a return to winning ways this afternoon
Anthony Martial has been dropped from the squad after struggling against Liverpool last weekend.
Juan Mata takes his place after excelling against the Reds at Old Trafford.
Marouane Fellaini has also been rewarded for his substitute cameo with a place in Jose Mourinho's Manchester United starting XI.
The Belgium international replaces Michael Carrick, who drops to the bench.
Marouane Fellaini starts for Manchester United
Wayne Rooney arrives at training in shocking new £250,000 orange supercar
Fri, January 20, 2017
Wayne Rooney is spotted driving a new £250,000 orange Bentley to training
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Wayne Rooney has added a shocking orange Bentley to his fleet of supercars
Daley Blind replaces Matteo Darmian.
And Chris Smalling comes in for Marcos Rojo.
There is a place among the subtitutes for Bastian Schweinsteiger, who has spent much of the season in exile.
Stoke, meanwhile, name the same side that beat Sunderland last weekend.
Wayne Rooney and Anthony Martial miss out for Manchester United
There is no place for new signing Saido Berahino, who was not registered in time for today's clash.
Stoke: Grant, Johnson, Shawcross, Martins Indi, Pieters, Whelan, Adam, Shaqiri, Allen, Arnautovic, Crouch
Subs: Given, Bardsley, Muniesa, Afellay, Imbula, Bojan, Ngoy
Manchester United: De Gea, Valencia, Jones, Smalling, Blind, Fellaini, Herrera, Mata, Pogba, Mkhitaryan, Ibrahimovic
Subs: Romero, Darmian, Carrick, Schweinsteiger, Lingard, Rashford, Rooney