Ibrahim Afellay is set to miss the rest of the season
Afellay has been ruled out for up to six weeks after his latest surgery, meaning he is unlikely to figure before the summer.
The Dutchman returned in December after eight months out with a cruciate ligament problem.
But the former Barcelona man, 31, has now picked up a fresh problem.
Boss Mark Hughes said: “Unfortunately we’ve lost Ibi Afellay for a number of weeks.
“He’s got a problem with his knee and he’s had surgery in Barcelona.
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“It’s five or six weeks and we’ll see if he’s back before the end of the season.”
Wales midfielder Joe Allen will also miss Saturday’s meeting with Hull because of a hamstring injury.
But Hughes believes Allen will be fit to face former club Swansea a week later.
Jon Walters is also a doubt with a knee problem.
Meanwhile, Hughes is refusing to rush goalkeeper Jack Butland back into first-team action after he returned from a year on the sidelines this week.
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Stoke are refusing to rush Jack Butland back from injury
Butland completed 90 minutes in an under-23s defeat at Brighton.
“I think there’s an amount of work he still needs to do,” said Hughes.
“When you’re out for a long time there are a number of boxes before the player, his coaches and I’m comfortable.
“I’m not sure we’re there yet but he’s very close.
“We got him a game this week and there’s another on Monday if we decide whether he would be better off with more game time or more training and shot-stopping work.
“The important thing is that he’s really comfortable with where he is.”