The England international has made two appearances off the bench since recovering from injury gets the chance to play from the beginning at the St Mary’s.
Theo Walcott also starts after injury while Lucas Perez, Rob Holding, Kieran Gibbs and Hector Bellerin also come into the side.
Francis Coquelin, Aaron Ramsey, Olivier Giroud, Mesut Ozil and Laurent Koscielny are rested ahead of a busy week.
Southampton: Lewis; Martina, Gardos, Stephens, McQueen; Reed, Clasie, Hojbjerg; Sims, Long, Isgrove
Subs: Taylor, Yoshida. Bertrand, Davis, Romeu, Redmond, Tadic.
Arsenal: Bellerin, Mustafi, Holding, Gibbs; Oxlade-Chamberlain, Maitland-Niles; Walcott, Reine-Adelaide, Lucas, Welbeck
Subs: Martinez, Mertesacker, Gabriel, Jenkinson, Monreal, Iwobi, Alexis.
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Arsenal stars fool around in training ahead of Southampton FA Cup clash
Fri, January 27, 2017
Arsene Wenger's Arsenal squad looked in a relaxed mood as they trained ahead of their FA Cup Fourth Round clash with Southampton on Saturday (5.30pm)
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Arsenal were in a relaxed mood training ahead of their clash with Southampton
Danny Welbeck starts upfront for ArsenalOriginal Article