Isco has been linked with Chelsea move
Isco could leave Real Madrid this summer after falling out of favour under Zinedine Zidane.
The Spain international has started just 14 of his 22 La Liga games this season, scoring six goals along the way.
Sergio Ramos says Isco is better off at Real Madrid
Blues boss Antonio Conte is keen to improve his squad ahead of their return to the Champions League next season, with Isco's team-mates James Rodriguez and Alvaro Morata also said to be on his shortlist.
But Real captain Ramos believes Isco, who cost £23m from Malaga in 2013, is better off staying at the Santiago Bernabeu.
Isco has fallen out of favour under Zinedine Zidane
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Speaking to Spanish TV channel Cuatro, Ramos said: “We hope that he stays.
"He is very calm and happy, leaving aside everything that is being said about his future.
“He is not going to be better [off] elsewhere than he is at Real Madrid.”