Manchester United have reportedly been tracking the progress of Guedes over the past few months.
Last week it was reported that the player's agent Jorge Mendes met with Benfica president Luis Filipe Vieira over a potential transfer to United.
And Portuguese outlet Record claim Guedes is set to leave Benfica in the coming days for a fee of around £26million.
Goncalo Guedes was left out of Benfica's squad yesterday
Rui Vitoria said Guedes' omission was more of a tactical switch
It is said he is set to join Manchester United or Paris Saint-Germain.
The 20-year-old attacker has been involved in 16 of Benfica's Primeira Liga matches so far this season, missing just one prior to yesterday's 4-0 win.
But Benfica boss Rui Vitoria has insisted that the Portugal international will leave this month.
Jose Mourinho wants to bring Goncalo Guedes to Old Trafford
“I understood that it was not the game for Goncalo Guedes to play," said Vitoria.
"I have to take options, there are more players in Benfica and I chose.
"I have no indication that he will leave.”