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The Labour and Conservative leader will face questions from the audience in York separately
Theresa May has blasted the bureaucrats in Brussels while reaffirming her insistence not to hold another vote on EU membership.
She dismissed holding a second referendum, something the lib Dems have been pushing for, on the terms of the Brexit deal.
Mrs May said: “Over the years in the European Union and its European economic community there have been a number of occasions where referendums have been held in countries, there was one in Ireland, I think France is an example as well, where ethic voted against what the EU was suggesting.
“And basically the bureaucrats and the EU politicians turned round to the countries and said you’ve got it wrong, have another vote we want we want you to come up with what we think is the right answer.”
It was important to listen to the will of the people and deliver Brexit, she said, not bow down to pressure and hold a second vote, something which would have delighted Brussels who voiced their displeasure with the No vote.
The two leaders will face questions on the BBC show from 8.30pm on Friday night, but will not go head-to-head.
The Labour and Conservative leaders will face questions from the audience in York separately, in one of two election programs to be aired in the run-up to the crucial vote on June 8.
The Q&A sessions comes just days after Mrs May refused to take part in a seven-way leaders debate on Wednesday, sending Home Secretary Amber Rudd in her place.
She was widely criticised for her no-show, something rival Jeremy Corbyn attempted to capitalise on.
The 90-minute program will not see the pair debate, whichTheresa May has actively tried to avoid.
The format is similar to when the pair faced questions from Jeremy Paxman on May v Corbyn Live: the Battle for No 10 earlier this week.
They were quizzed on a range of topics including nuclear disarmament, Brexit, schools and social care policy.
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The second Question Time debate takes place on Sunday night between Liberal Democrat leader Tim Farron and Scottish National Party’s Nicola Sturgeon.
Express.co.uk will be giving you live updates on the crunch Question Time debate. Follow our coverage below.
Security has been ramped up at the University of York
9.15pm update: After facing questions on education and the NS, she is now being grilled over her stance on Donald Trump pulling out of the Paris Agreement.
When asked what she said, she said he has taken the decision backs ehe thinks its in the best interest for America.
“I’ve told him my views.”
9.13pm update: A quality education was not just about pumping money into schools, but the “innovation and creativity” in education.
8.58pm update: “In the five years to 2020 we will be spending half a trillion on the NHS.”
8.57pm update: Mrs May is setting out why they are not following the Dilnot recommendations.
8.55pm update: She said they were going to “consult with people, consult with voters, consult with organisations” before imposing any figures.
8.53pm update: "We'll consult on the cap."
"If we do nothing our social care will collapse."
Speaking on her social care u-turn, she was defending he figures against Mr Dimbleby, pointing out there is a “cap and a floor”, which she was challenged over as the host said it was not in their manifesto.
8.51pm update: Defending her manifesto, the lack of costing and the u-turns, she said as a politician on the whole: “We are asking people to trust us.”
8.50pm update: Responding to calls she should have the “confidence” to call a second vote she referenced previous referendums in various EU countries.
She said: “Let’s listen to the people and actually deliver on it.”
8.48pm update: An audience member pointed out despite her comments about Ms Abbott chancellor of the exchequer Phillip Hammond made a £20 billion mistake.
8.47pm update: “They want to start off talking about the bill.”
A good deal in trade terms would benefit not just the UK but the remaining 27 members, she said.
8.46 update: Mrs May could not give a figure for what a “good deal” would look like for the UK.
8.44pm update: Defending her record as a Remain voter, she said: “I also said the sky will not fall in if we leave the EU”.
8.43pm update: She was grilled over what she thought a ‘bad deal’ for Brexit is, and is now explaining how she can represent the whole of the UK when only 52 per cent voted to leave.
Mr May said she "believes in the British people" and called Brexit an "opportunity".
8.41pm update: She is once again having to defend her refusal to debate with the other leaders, calling it “more useful” to be out and about listening to voters.
The PM called it “seven politician arguing among themselves”.
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8.40pm update: A passionate audience member as told her calling an election will “backfire”.
Mr May has said she could have easily stayed in the job, but called the election for the good of the county.
8.38pm update: When asked how she felt now the polls showed her lead over Labour thinning considerably, she said the only poll that mattered is the one on the day.
Mr Dimbleby now asks if she is “surprised” her lead has dropped from 20 points to five.
8.37pm update: “We got the article 50 legislation through parliament . . . whoever comes in as a prime minister as a government has to be ready to get the ball rolling.”
She said it was “clear” other parties wanted to frustrate the Brexit process. She took another swipe ta Ms Abbott, saying she "can’t add up."
Sshe said the only poll that mattered is the one on the day
8.35pm update: “I’ve called an election because of Brexit.”
8.34pm update: The audience member is now taking Mrs May to task, detailing all her u-turns and policy swerves. She also attempts to defend why she did not take part in the leaders' debate.
8.33pm update: When quizzed over he backtracking and u-turns as her time as Home Secretary and Prime Minister, Mrs May is reeling off a list of her achievements. She also took a swipe at shadow Home Secretary Diane Abbott.
8.30pm update: The BBC show is underway with Mr Dimbleby opening up the programme. He says one third of the audience are backing Conservatives, Labour or are undecided.
He confirmed they do not know the questions being asked to them, and Mrs May is up first.
8.20pm update: Theresa May and Jeremy Corbyn have been seen entering the University of York ready for their sit-down with David Dimbleby.
Security has been ramped up at the University of York, with an increased police presence stationed around the building.