Charles, 68, was presented with the Statue of Remembrance, an honour that has also been given to world figures like Pope Francis, former secretary-general of the United Nations Ban Ki-moon and German chancellor Angela Merkel.
The heir to the throne is patron of the Holocaust Memorial Day Trust.
Prince Charles spoke to survivors of the Holocaust and other genocides at St. James' Palace
Over past decades, he has visited many different faith groups in the UK and abroad, from Hindu and Muslim communities to Syrian Christians and Jewish groups, promoting tolerance.
The International Auschwitz Committee has been awarding the statue since 2010 to public figures who speak out worldwide for human rights and stand up against intolerance and anti-Semitism.
He was presented with the Statue of Remembrance
Prince Charles is a Patron of The Holocaust Memorial Day Trust
The award is an upside down letter B, a reference to the same letter from the infamous motto above the gates of Auschwitz concentration camp – Arbeit Macht Frei, work sets you free.
Prince Charles also speaks out very clearly in his determined efforts to inspire people
Christoph Heubner, International Auschwitz Committee
When prisoners were forced to build the sign they chose to invert the letter in a spontaneous act of courage and defiance.
Christoph Heubner, the executive vice president of the International Auschwitz Committee, said: "The survivors of the Holocaust are deeply moved and profoundly impressed by the empathy that the Prince of Wales has repeatedly expressed over the years for their painful memories, and by his acute insight into the causes and consequences of the Holocaust.
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Over the past decades he has visited many different faith groups and promoting tolerance Prince Charles in pictures Fri, December 16, 2016
Prince Charles as he tours the world for his royal visits.
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Prince of Wales in Clarence House, London as he records a special message for BBC Radio 4's Just a Minute as it enters its 50th anniversary year which will be aired on Christmas Day
"Prince Charles also speaks out very clearly in his determined efforts to inspire people to overcome the new hatred and age-old prejudices."
During the presentation, being held at St James's Palace, Charles hosted a reception for Holocaust survivors and their families as well as those who have lived through genocides in Cambodia, Rwanda, Bosnia and Darfur.
The Prince also met representatives from the Holocaust Memorial Day Trust and heard about work to promote and support Holocaust Memorial Day in the UK.