Images on social media show a deserted tube station and as police attended the scene
Dozens of police officers descended on the scene and commuters were urged to leave the area.
Bus and underground links to the busy station were suspended as authorities investigated the package.
The news comes just hours after a devastating terror attack in Westminster left five people dead and around 40 injured.
Commuters quickly took to social media following the station closure.
One Twitter user wrote: “There's a suspicious package at north greenwich. stay safe all.”
The North Greenwich tube station, on the Jubilee line, was evacuated at around 11pm
Another added: “Bit scary. Came out the cinema at the o2 to find North Greenwich station is being evacuated due to a suspicious package. Police everywhere.”
A Met Police spokesman confirmed the station was closed for a short period but was reopened after officials confirmed the package was not suspicious.
The news comes despite an increased security presence in London following Wednesday’s terror attack, which has been branded “sick and depraved” by the Prime Minister.
The station is located close to the O2 Arena, one of London's tourism hotspots
Five people have died and 40 have been injured after a major terror attack in the heart of the capital.
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A car ploughed through a crowd of people on Westminster Bridge shortly after 2.30pm this afternoon, killing at least two.
The car, a grey Hyundai i40, then continued down towards Parliament before colliding into a gate.
London Terror Attack: LIVE PICTURES Wed, March 22, 2017
Two dead, 12 injured as knifeman mows into crowd in Westminster
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Conservative MP Tobias Ellwood (centre) helps emergency services attend to a police officer outside the Palace of Westminster, London
The attacker then attempted to storm into Parliament before being confronted by a police officer, named this evening as Keith Palmer.
Mr Palmer, a 48-year-old husband and father, was fatally stabbed while stopping the killer.
The attacker was then shot dead by another officer.
Another member of the public was also killed in the attack, although police have not specified where this fatality occurred.
Two other police officers are in a serious condition, along with several members of the public.