The Good Morning Britain presenter, who was jeered at while on stage at the National Television Awards this week, has wished those who want him dead "good luck".
Speaking after a member of the audience shouted "shoot him" while he presented an award with co-host Susanna Reid, Piers said: "A few morons shouting at me… what is he going to shoot me with? His d**k?
"Let's be honest now, from what I hear, it's not the biggest."
The controversial host went on to insist: "I honestly don't worry about being a target. When I was in America at CNN, I did a campaign about gun control and I was getting death threats every three minutes."
Susanna Reid gagged Piers Morgan on stage at the National Television Awards
Piers revealed he received death threats every minutes on CNN
What is he going to shoot me with? His d**k?
It wasn't just his appearance on the US network that garnered a lot of negative attention, Piers has also received abuse on social media due to his comments on British TV.
But, the 51-year-old said he doesn't care, telling The Sun: "I've never had security, I take care of myself. If someone wants to try their luck then good luck to them!"
It comes after he sparked another debate about women wearing high heels for work when he tweeted about Julia Roberts.
Piers offered examples of when he thought it would not be unreasonable for an employer to ask female staff to wear heeled shoes.
Piers hosts Good Morning Britain alongside Susanna Reid
Piers Morgan's most famous Twitter spats
Thu, September 22, 2016
Good Morning Britain host, Piers Morgan's most outrageous quotes and Twitter spats.
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Piers Morgan's most outrageous quotes
Piers sparked more debate when he tweeted about Julia Roberts at Cannes Film Festival
He posted on Twitter: "I haven't told anyone they HAVE to wear them. Just wonder if there are certain jobs where it's not unreasonable for an employer to ask?
"In a high-end shoe shop, for instance, is it unreasonable for the boss to request female staff wear the heels you sell?
"I loved Julia Roberts going barefoot at Cannes to protest at heels directive from Festival crusties. But they weren't her employers."