The Blues beat United 4-0 at Stamford Bridge back in October, while they also knocked the Red Devils out of the FA Cup after a 1-0 victory last month.
And they will be looking to make it a hat-trick of wins against Jose Mourinho's side at Old Trafford this weekend.
Paul Merson has revealed how Manchester United can beat Chelsea
But Merson believes Antonio Conte’s side can be beaten on Sunday (4.00pm).
“The only team that have really shown how to beat their system are Tottenham, which was because Chelsea had played quick games in succession. The way they play with wing-backs, it's hard to do that without a break,” Merson said.
“The way I'd play would be like we used to at Arsenal when we played that system, with one up front and two out-and-out wingers, then the wingers stay wide and don't track back.
Manchester United v Chelsea combined XI Wed, April 12, 2017
Express Sport brings you our combined XI of Manchester United and Chelsea stars ahead of the Premier League clash at Old Trafford on Sunday (4pm)
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Who makes our combined Manchester United and Chelsea XI?
“That way you're either asking the central defenders to come out wide, where the likes of Gary Cahill don't want to go, or make their wing-backs come back into a five, reducing their threat and giving Eden Hazard and Pedro less support.
“That's what Manchester City did and they had a lot of the game but just couldn't grind out the result.
“It's obviously not easy to do that but I think you've got to have bottle if you want to beat Chelsea.”
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