Pat Nevin says pressure on Jose Mourinho at Stamford Bridge
Premier League leaders Chelsea, who beat United 4-0 at home earlier on in the season, are favourites to progress to the semi-finals.
Jose Mourinho goes head to head with Antonio Conte in FA Cup quarter finals
And former Blues winger Nevin believes the pressure is on Mourinho to make alterations to his side in a bid to progress in the FA Cup.
Nevin told Chelsea's official website: "I suspect Antonio [Conte] will not bother changing for anyone anyway.
"It is up to the others to adapt to Chelsea right now and that includes Jose Mourinho and Manchester United.
Fans react to FA Cup quarter-final draw
Sun, February 19, 2017
Express Sport brings you all the best tweets as fans react to the FA Cup quarter-final draw
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"Jose might know Chelsea and most of the players better than just about anyone, but most teams appear to know what Chelsea are doing, they just can’t seem to find a way of stopping it.
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"Even when the team plays just fairly well, it tends to still be enough."