Many of the young people are believed to be Saint-Denis students
Police estimate between 80 and 100 students took to the streets, hurling stones at officers as well as throwing molotov cocktails and launching fireworks in acts of destruction.
At 11am, several individuals were able to enter the Suger college, north of central Paris, and start three fires in the building.
A witness added: "They were throwing Molotov cocktails and firing mortar fireworks into the premises."
But while police attended the scene, in a bid to quell the violent acts, they faced further aggression.
Police on the scene had stones hurled at them
One officer said: "At about 11 am smoke was thrown into the compound.
"The air became unbreathable and the headmaster decided to evacuate and close the facility, which had already been disturbed the day before by incidents."
The arrests follow a series of violent protests following the alleged rape of a young black man by French police with a truncheon.
Paris erupts in violence following police brutality Thu, February 23, 2017
Students gather during a demonstration against police brutality, following the alleged rape of Theo, outside the 'Lycee Voltaire' secondary school in Paris
Play slideshow AFP/Getty Images 1 of 17
Members of the riot police charge at demonstrators during a protest of students against police brutality, following the alleged rape of Theo in Paris
Get Quotes on Home Insurance
A group had entered the school earlier that morning
The man, identified only as Theo L, remains in hospital with injuries after his arrest and alleged abuse on February 2.
Police looking to stem the tide of chaos outside the Saint Denis Suger High School claim they heard "slogans like 'revenge for Theo'".
- BLOODY VIOLENCE IN ROME: Taxi drivers fight with police at angry demo
- Sweden riot: MP demands surveillance as police overpowered by mob
- US comedian shockingly jokes about crime levels as Sweden burns