Pakistan will have to take on the Proteas without Wahab Riaz, who will play no further part in the Champions Trophy after suffering an ankle problem during their defeat by arch-rivals India in their Group B clash on Sunday.
Riaz, who had conceded 87 runs in 8.4 overs, left the field in the 46th over of India's innings and scans confirmed the 31-year-old suffered a deltoid ligament complex injury.
The Pakistan Cricket Board said in a statement that it had sent an official request to the ICC technical committee to call up a replacement, which has yet to be approved.
Apart from Mohammad Amir and Hasan Ali, who both played against India, Pakistan's other pace bowling options are Junaid Khan and all-rounder Faheem Ashraf.
Pakistan who lost by 124 runs on the Duckworth/Lewis method in a rain-shortened match against India, next face South Africa in their second group game at Edgbaston on Wednesday.
South Africa beat Sri Lanka in their first match.