The 32-year-old – a doting uncle to his brother's children Prince George and Princess Charlotte – said having children was now very much on his radar.
He told the Daily Telegraph: “Of course I would love to have kids.”
The Prince said he was now in a 'good place' and finally in a position to take his private life 'seriously'.
Prince Harry said he would love to have children
Prince Harry has spoken at length about his mental health battles
Of course I would love to have kids
Harry is still keen to avoid questions about his love life but has been dating US actress Meghan Markle for nine months and is said by pals to be 'besotted'.
He flew to Toronto to spend Easter with the 35-year-old Suits star who is also a charity campaigner and had been seen wearing a gold ring featuring what appeared to be the letter 'H'.
When news of their relationship emerged last year, Harry urged 'racist and sexist' online trolls to leave her alone amid fears the intense scrutiny would drive her away.
Prince Harry is enjoying a relationship with US actress Meghan Markle
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In a statement which confirmed their relationship, the Prince accused mainstream and social media of 'crossing a line'.
The Prince said it was not right that Ms Markle 'should be subjected to such a storm'.
The pair have since enjoyed string of romantic holidays since announcing their relationship last summer.
Prince Harry said he was now taking his work and private life seriously Prince Harry in pictures Tue, March 21, 2017
Prince Harry royal visits around the world and a mixture of all the charitable work he's done.
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Prince Harry during a visit to Hamilton College on March 21, 2017 in Leicester
Meghan has also stayed with Harry in his cottage at Kensington Palace.
Prince Harry previously dated Chelsy Davy and model Cressida Bonas, who was unhappy with the constant attention she received in public.
In the interview with the Daily Telegraph, he said: “I’ve now been able to take my work seriously, been able to take my private life seriously as well.”