Talking during in impromptu public meeting at the Bellringer pub in the city's Eaton Park neighbourhood, the MEP promised to replace Labour as the party of the "patriotic working class".
“If this constituency elects a Ukip MP on February the 23rd it will send shockwaves through the establishment ,” he said.
“I guarantee it will put stoke on trent central on the political map. Money will come to this area, because people will be terrified that if Stoke on Trent Central goes there will be others that go after it.
Paul Nuttall roused the crowd with an impassioned speach about what he would do in Westminister
If this constituency elects a UKIP MP on February the 23rd it will send shockwaves through the establishment
“We can replace them as the patriotic voice of working people, and we will do so. It will take time but we can make that first step on February the 23rd – and I genuinely believe that we will."
The assembled crowd in the pub can be heard reacting enthusiastically to the speech.
Mr Nuttall continued: “If people go out and vote for Labour again and get a Labour MP, nothing will change.
"It will be the same, time and time again. It will be a voice in the wilderness. It will be lobby fodder.
“I guarantee, and I say this to the residents, If you go out and vote for me – things will change and things will change quickly.
Gareth Snell walks through Hanley town centre in Stoke-on-Trent
The by-election will be seen as a key bellwether on whether Ukip can make an electoral success in traditionally Labour-held northern areas which backed Brexit.
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Mr Nuttall’s campaign was dealt a blow after he was forced to concede claims made on his website that he had lost a "close personal friend" at the Hillsborough tragedy were untrue.
But he has blasted back at reports he never attended the infamous football match in 1989.
"I just want to make it perfectly clear. I was there on that day. I've got witnesses, people who will stand up in court and back me 100 per cent," he said.