The former Ukip leader bashed those “close to the President” as he had “yet to hear one sensible explanation” for what would replace Syrian President Bashar al-Assad.
The US action on the Sharat airbase in Homs comes after a chemical attack in Idlib last week, which killed at least 80 people.
Speaking on Fox News, the MEP said: “I think it’s a real problem in this part of the world trying to pick the good guys from the bad guys because what happens once Assad is gone?
“Because you listen to Secretary of State Tillerson, Boris Johnson from our country and what’s pretty clear is the West is now calling for regime change, they’re calling for Assad to be gone.
Nigel Farage has criticised America's missile strikes on Syria
I’ve yet to hear one sensible explanation of who or what is going to replace him
“I’ve yet to hear one sensible explanation of who or what is going to replace him.”
The Brexiteer then brought up Britain and America’s role in ousting Saddam Hussein in Iraq and Colonel Gaddafi in Libya.
He said: “There are many people around the President and close to the President who are really being quite explicit in saying they want regime change.
“We did this in Iraq, we did this in Libya, I just wonder what the alternative is.”
NATO meets Donald Trump months after he described it ‘obsolete’
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U.S. President Trump meets with NATO Secretary General Stoltenberg at the White House in Washington
Nigel Farage speaking at a Donald Trump rally last year
The comments come after he called for an investigation into last week’s chemical attack.
He said: “I have to say I do rather agree with Sergei Lavrov, let's have an investigation, let's send in the United Nations or someone like that and let's find out the truth.”
Mr Trump has claimed the Syrian government was responsible for the chemical attack.
After the US airstrikes, he said it was in the “vital national security interests” of the US to “prevent the spread and use of chemical weapons”.
He said: ”There can be no dispute that Syria used banned chemical weapons, violated its obligations under the Chemical Weapons Convention and ignored the urging of the UN Security Council."