State agency KCNA made the furious declaration as the nation celebrated 'Day of the Sun' with a military parade.
It added the actions of the US, which last week hit Afghanistan with a huge missile attack on Islamic State, "could not be overlooked".
North Korea’s military also vowed to take the “toughest counteraction” against the United States and South Korea, as tensions over the hermit nation’s nuclear weapons program continue to escalate.
Relations on the Korean peninsula are at breaking point after US officials refused to rule out using military force against Kim Jong-un’s relentless drive to bolster his military’s nuclear arsenal.
A North Korean military official told state media: "Our toughest counteraction against the US and its vassal forces will be taken in such a merciless manner as not to allow the aggressors to survive.
“North Korea’s military will as ever courageously counter those who encroach upon the dignity and sovereignty of the DPRK and will always mercilessly foil all the provocative options of the US with Korean-style toughest counteraction."
Donald Trump this week sent a Naval strike team spearheaded by the USS Carl Vinson warship to the Japan Sea in a bid to deter the North Korean regime.
The team is expected to arrive at its point of registration on April 18.
North Korea has threatened to retaliate against Trump's deployment of Naval forces in the Japan Sea
Inside North Korea: The pictures Kim Jong-un doesn't want you to see
Wed, April 12, 2017
Photographer Eric Lafforgue ventured to North Korea six times. Thanks to digital memory cards, he was able to save photos that was forbidden to take inside the segregated state
Eric Lafforgue/Exclusivepix Medi
Get Quotes on Home Insurance
1 of 69
Taking pictures in the DMZ is easy, but if you come too close to the soldiers, they stop you
Military parades in Pyongyang today displayed submarine-launched ballistic missiles
The developments come as North Korea celebrates the 105th anniversary of the birth of its founder, Kim Il-sung.
Kim Jong-un’s military is expected to carry out an intercontinental ballistic missiles drill amid the festivities, as part of a display of military might for countries overseas to witness.
North Korea also accused the US of attempting to “blackmail” the country with its missile strike on a Syrian airbase last week.
The North Korean leader watched over the festivities as thousands of troops marched in celebration
North Korea May Be Preparing a Nuclear Test for Kim Il-Sung’s Birthday
Fri, April 14, 2017
North Korea has begun preparing festivities for the 'Day of the Sun,' a holiday celebrating communist leader Kim Il-Sung
1 of 9
Military officers visit the birthplace of North Korean founder Kim Il Sung, a day before the 105th anniversary of his birth, in Mangyongdae, just outside Pyongyang
A statement from the military said: "In actuality, the Trump administration, which made a surprise cruise guided missile strike at Syria on April 6, has entered the path of open threat and blackmail against the DPRK, describing it as 'a strong warning message' to it.”
North Korean Vice Foreign Minister Han Song-ryol confirmed in an interview the country would conduct another nuclear test at any point Kim Jong-un wishes to.
He said: “If the U.S. comes with reckless military manoeuvres then we will confront it with a pre-emptive strike."