Hamilton won from pole in 2016 with his team-mate Nico Rosberg back in seventh, closing the gap at the top of the World Drivers’ Championship to 24 points.
And he once again finds himself trailing a German driver in Vettel, although the gap is just six points and he knows that winning the race will see him head to Canada with the championship lead.
Qualifying will be crucial on such a narrow track where overtaking is notoriously difficult – so here’s how to make sure you don’t miss any of the action.
How can I watch the Monaco Grand Prix 2017 qualifying live on TV?
The Monaco Grand Prix will be shown across two different TV stations in the UK with Channel 4 and Sky Sports both having bought the rights to the race.
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Channel 4’s coverage of Saturday’s qualifying session will run from 11.55am with the on-track action getting underway at 1pm.
Sky meanwhile will air their offering on their dedicated Sky Sports F1 channel after The F1 Show (11.30am), starting at 12pm.
How can I stream the Monaco Grand Prix 2017 qualifying live online?
Channel 4 is available to stream live online in the UK through their website.
Lewis Hamilton has twice won the Monaco Grand Prix, once from pole and once from third on the grid
Sebastian Vettel will hope to maintain the WDC lead at the Monaco Grand Prix
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But if you’d rather watch the Sky Sports version of events online, all the action can be followed on your desktop or laptop via the Sky Go app, which if you’re an existing customer, is also available on iOS and Android smartphone and tablet devices.
Sky Go is also available on a number of platforms including Amazon Fire devices, iPad, Mac computers and laptops, Playstation 3, PS4 and Xbox One.
The Sky Sports app, available to download on iOS and Android devices, will also be providing live text coverage and updates.
If you're not currently a Sky Sports customer but can't stand to miss out on the Sky action, you can add the channels to your box via a NOW TV subscription.
Day passes, which let you add Sky Sports channels for 24 hours, start at £6.99 a day, with a weekly pass starting from £10.99, and no locking in to a contract.
NOW TV doesn't even require a typical television to use, as it is also available on a NOW TV Box, Chromecast, PS4, PS3, Xbox One, Xbox 360, Roku, LG Smart TV, PC or Mac, and selected mobile and tablet devices.