Chelsea will be aiming to keep hopes of the double alive when they visit the Championship side by making it eight games unbeaten in all competitions.
Paul Lambert's side caused the shock of the fourth round by beating Liverpool 2-1 at Anfield.
Jurgen Klopp opted for an under-strength Liverpool side for that match but Antonio Conte is unlikely to field a similar weakened team.
Michael Owen expects Michy Batshuayi to continue his good form in the FA Cup
Michy Batshuayi has started each of Chelsea's FA Cup matches so far this season
Chelsea predicted team to face Wolves in FA Cup
Thu, February 16, 2017
Express Sport brings you Chelsea's predicted team to face Wolves in the FA Cup Fifth round this weekend
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Who could Antonio Conte start against Wolves in the FA Cup?
But one player expected to be given his chance in the cup match is back-up striker Michy Batshuayi.
The 23-year-old is yet to start a single Premier League game this season but he has scored in both of Chelsea's FA Cup matches to date.
And Owen predicts the Belgium international to continue that trend against Wolves.
"The last side to knock out Liverpool and Chelsea in the FA Cup in the same season was Barnsley back in the 2007/8 season but I can’t see Wolves joining the Tykes," Owen told betvictor.
"Paul Lambert’s sides form has dipped in recent games losing their last three in the Championship including back-to-back 1-0 home losses to Newcastle and to Wigan earlier in the week.
"Chelsea are unlikely to make as many changes as many of the top clubs given they have no European engagements to worry about but I expect Michy Batshuayi to get a start and he is taken to make the most of his opportunity."