Manchester United want to sign Guedes to replace Memphis Depay.
The Portugal international has enjoyed a fine season, scoring seven goals from 28 games.
His fine form has led to both United and Paris Saint-Germain registering an interest in a January transfer.
Goncalo Guedes looks set to leave Benfica
Manchester United are on the lookout for a replacement for Memphis Depay
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Despite signing Julian Draxler, PSG are keen to muscle in on United's bid for the winger.
And Portuguese newspaper Record claim Guedes is set to say goodbye to Benfica fans later today.
The 20-year-old will not feature in Benfica's clash with Tondela (4pm) despite being included in Rui Vitoria's squad.
Goncalo Guedes has been in fine form for Benfica this season
He will instead use the occasion to thank the club's supporters before leaving for pastures new.
It is currently unknown what club Guedes will sign for.
The youngster is expected to depart for a fee of around £26million.