Rooney has been absent with an ankle injury since Manchester United's goalless draw with West Brom on April 1.
The England international has endured a rough season under Jose Mourinho – managing just five goals across all competitions.
However, Mourinho has confirmed he could return against Anderlecht when the two teams face off in the Europa League tomorrow (8.05pm).
Wayne Rooney could return for Manchester United against Anderlecht Manchester United's predicted team to face Anderlecht Tue, April 18, 2017
Express Sport brings you Manchester United's predicted team to face Anderlecht in the Europa League quarter-final second leg at Old Trafford
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Who could Jose Mourinho start against Anderlecht at Old Trafford?
"He's working, he's improving and, if in this session the answer is positive, I will select him to be on the bench tomorrow," he said.
"His experience, his know-how of this knock-out phase – I think he's a player that can be useful tomorrow. He can help us."
Wayne Rooney has fallen down the pecking order at Manchester United this season
United are expected to restore Zlatan Ibrahimovic to the starting line-up after the Swede missed their 2-0 win over Chelsea on Sunday.
The Red Devils are aiming to make the last four of the competition with the tie currently evenly poised after a 1-1 draw in Belgium last week.
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