Henderson was sent on loan to the League Two club back in August.
The 19-year-old had his deal with Grimsby extended until the end of the season last month.
Dean Henderson has been recalled from his loan at Grimsby by Manchester United
But he has now been recalled by Manchester United as they prepare for Sunday's trip to Leicester.
Henderson made seven appearances for Grimsby, keeping four clean sheets in the process.
And the Manchester Evening News claim Henderson’s loan spell at Grimsby has been ended following a significant injury to one of United’s first-team squad goalkeepers.
Man United stars bring out 4x4s to tackle farm track to and from training
Thu, February 2, 2017
Manchester United stars were forced to roll out their fleet of off-road vehicles as they made their way to and from training down a dirty farm track
1 of 14
Manchester United stars are forced to take a farm track to and from training
United currently have Sergio Romero and Joel Pereira providing cover for David de Gea.
Pereira made his debut on Sunday against Wigan but was not used as the warm-up goalkeeper for the visit of Hull in midweek.
Get Quotes on Home Insurance
Instead Kieran O'Hara, who is the club’s second choice for the Under-23s, was called up.