The two teams drew 1-1 in Belgium last week.
Manchester United are favourites to progress after Henrikh Mkhitaryan bagged a crucial away goal.
Manchester United's predicted team to face Anderlecht Tue, April 18, 2017
Express Sport brings you Manchester United's predicted team to face Anderlecht in the Europa League quarter-final second leg at Old Trafford
Play slideshow Getty Images 1 of 12
Who could Jose Mourinho start against Anderlecht at Old Trafford?
Henrikh Mkhitaryan scored a vital goal in the first leg
Mourinho has been known to shut up shop when his teams have a lead to defend in Europe.
But the former Chelsea manager insisted United would try to put the tie to bed.
"First of all, if you don't concede, you go through, and that's important for us to know," he said.
Jose Mourinho has confirmed Manchester United will attack Anderlecht tomorrow night
"At the same time, Anderlecht know that if they don't score, they're out. Let's see what happens.
"We play at home and I know our record there in the Premier League is not the best, but in the Europa League we've won every match at home.
Get Quotes on Home Insurance
"Are we going to play for a 0-0? No."