Martial is one of nine changes for the team which reached the EFL Cup final on Thursday.
Bastian Schweinsteiger makes his first start of the season in midfield alongside Marouane Fellaini.
Wayne Rooney leads the attack, supported by Henrikh Mikihitaryan, Juan Mata and Martial.
Manchester United: Romero, Fosu-Mensah, Smalling, Rojo, Shaw, Fellaini, Schweinsteiger, Mikihitaryan, Mata, Martial, Rooney
Subs: Pereira, Blind, Tuanzebe, Herrera, Young, Ibrahimovic, Rashford
— Manchester United (@ManUtd) 29 January 2017
Manchester United line-up predicted to face Wigan Athletic
Fri, January 27, 2017
Express Sport predicts the Manchester United line-up to face Wigan Athletic in the FA Cup Fourth Round at Old Trafford on Sunday (4pm)
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Express Sport predicts who will start for Manchester United against Wigan
Manchester United's Anthony MartialOriginal Article