Manchester United’s midfielder sustained a toe blow which has ruled him out of Tuesday’s friendly against Russia.
The 29-year-old started Saturday’s World Cup qualifier as Belgium drew 1-1 with Greece.
But Fellaini only lasted 66 minutes before being replaced by Mousa Dembele.
And the Red Devils have now confirmed the United star will not play again during the international break.
Marouane Fellaini played for Belgium on Saturday but is now out of Tuesday's game with Russia
Fellaini is expected to return to Manchester
As a result, Fellaini is expected to return to Manchester with Jose Mourinho’s side preparing to face West Brom at Old Trafford on Saturday (3pm).
It is unclear whether Fellaini will be fit for the Premier League clash.
And his availability is also uncertain for next Tuesday’s showdown at home to former club Everton.
Marouane Fellaini lasted just 66 minutes in Saturday's clash with Greece
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Jose Mourinho will hope Marouane Fellaini is back available ASAP for Manchester United
United are not the only team to have suffered an injury though, as Chelsea’s Belgian duo Eden Hazard and Thibaut Courtois are both out of the Russia game too.
Manchester City’s Kevin De Bruyne is another confirmed casualty ahead of their crunch trip to Arsenal on Sunday (4pm).
Mourinho will hope Fellaini is not sidelined for long, as United face a gruelling month of fixtures meaning the boss is set to rotate players.