Two goals from Paulo Dybala and a second half header by Giorgio Chiellini have left Enrique's men with another mountain to claim in the Champions League.
Barcelona were able to overturn a 4-0 first left deficit in the previous round to Paris Saint Germain.
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But Enrique believes his players didn't have the luck needed to get back into the game.
He said: "We put in a really bad first half.
Barcelona coach Luis Enrique
"In the second half we were even the better team but we conceded the third.
"On nightmare days like this one we have not had that touch of luck to get us back into the tie."