The 47-year-old ITV favourite began the show in an unusual fashion as she segued into a segment about insults by hurling a few at her co-stars.
"There's nothing like throwing a good insult when you're talking about someone you're not too keen on," Andrea said.
"Take Jane, the old bag," she continued. "Saira – gobby moo.
Andrea McLean lashed out at her fellow Loose Women stars
Andrea hurled a list of insults at the Loose Women Loose Women then and now Thu, March 2, 2017
Loose Women: From Janet Street Porter to Katie Price, see the Loose Women panel in their younger years.
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Katie Price in 1999 and now
"Don't look at me like that Coleen. She's so judgey." the Loose Women host added.
Luckily, the rest of the panel took her lighthearted name-calling in jest, laughing as she dished out the insults.
Andrea joked that Saira was a 'gobby moo'
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She called Coleen Nolan 'judgey'
The Prime Minister hit out at her opponent in the lead-up to the general election, saying that his performance in their recent live TV debate demonstrated that he would find himself "naked in the negotiating chamber" in Brexit talks next month.
She went on to joke that the image "doesn't bear thinking about", prompting awkward laughter from her audience of journalists and activists.
The Loose Women dissected the remark on today's show, with Jane Moore commenting: "I think the minute you get personal, you've lost the argument."
Loose Women airs weekdays at 12.30pm on ITV.