The 25-year-old was been linked with a move away for several years but has opted to remain loyal.
Arsenal made an offer for Lacazette last year but it was turned down by Lyon and he signed an extension to his contract.
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But it now appears as though the prolific forward is ready to ply his trade elsewhere.
“I think that the right moment has arrived to leave,” Lacazette told French outlet Canal+.
“I think that this summer I will need a change of scenery and discover something else, still with the idea of advancing and progressing in terms of football and as a person.
Alexandre Lacazette wants to leave Lyon
“I will continue to work, in the hope that good opportunities will come this summer.”
Arsenal could, however, face a difficult task convincing Lacazette to come to the Emirates if Barcelona came calling.
Lacazette says it would be a dream to join the Spanish side and follow in the footsteps of former Lyon team-mate Samuel Umtiti.
Alexandre Lacazette has an excellent goalscoring record
He added: “(Move to) Barcelona to join Umtiti? It is a very big club.
“They have extraterrestrials up front. It would be a dream.
“If that happens, great, but I am not here to say that I will take a place from Luis Suarez. But I would like to play for them one day.”