A taller man can be seen appearing to defend himself as he holds the wrist of a smaller man clutching the knife by the bus' front door.
The pair then wrestle just in front of the driver’s cabin on the new red double decker bus as another passenger films the gory incident.
Suddenly the taller man manages to rip the knife out of the other man’s clutches and the small man sprints out of the bus’ middle door and down the pavement towards a BP petrol station.
A shocked woman is seen stepping off the bus and pointing at the tall man as she says he is cut.
The camera then pans on to the man who is now holding the large knife, and has blood coming out of a few cuts on his wrist and hand.
He then says: “Do you want to call the police?”
The smaller man tried to stab the taller man
Then, shouting after his attacker who is sprinting away, he says: “I’m an African, you’ll never take my life.”
Scotland Yard has revealed to Express.co.uk the incident was on the 149 bus in Hackney, east London.
Shocking video stills as knifeman runs rampage on London bus Wed, April 12, 2017
Footage has emerged of a passenger wrestling a large knife off another man trying to stab him on a London bus in broad daylight
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A Met Police spokesman, said: “Police were called to Stoke Newington Road junction with Foulden Road, N16, at 13:55hrs on Tuesday, 11 April, to reports of a stabbing which had occurred on a bus.
“Officers and London Ambulance Service attended and found a man in his 20s with minor lacerations to his hand and head.
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“He was taken to an East London hospital where he was treated for his injuries. He has now been discharged.
The men wrestled with the knife in between them
The man who wrestled the knife from the other man held the blade as he asked a woman to call police
“The incident took place on the route 149 bus.
“There have been no arrests.
Annual statistics from Scotland Yard reveal there were an average of 33 knife offences a day in London in the last year.
The incident brings back memories of 2015's knife attack inside Leytonstone tube station in east London when Muhaydin Mire attacked three people with a bread knife as he said: "This is for Syria, my Muslim brothers."
A bystander was then captured on video shouting: "You ain't no Muslim, bruv."
The hashtag #YouAintNoMuslimBruv started trending the following morning and the phrase was even repeated by then Prime Minister David Cameron in the House of Commons.