Lewis Hamilton is desperate to win his fourth world title after missing out last year
Walker spent more than 50 years commentating on Formula One and became one of the most iconic voices in motor sport.
And he believes that if his Mercedes car continues to be one of the quickest on the grid, no-one can stop Lewis Hamilton becoming a four-time world champion.
“It all depends on the cars,” said Murray, who will act as a pundit for Channel 4 this season.
F1 2017 Drivers' World Championship standings Sun, April 9, 2017
Express Sport runs through the current F1 Drivers' World Championship standings
Play slideshow GETTY 1 of 21
Who is top of the F1 Drivers' World Championship after Round 2?
“It doesn’t matter if you’re the best driver in the world, if you haven’t got a car that enables you to exploit your talents, you’re not going to win.
“Lewis has had the best car. He is also one of the best drivers.
“So if you put one of the best drivers, in one of the best cars, and he doesn’t win, there is something wrong.
“The short answer is, yes, I do think Lewis Hamilton will be world champion again.
“But I do hope he gets a run for his money.”
Hamilton is currently tied at the top of the F1 World Drivers’ Championship after Vettel won the Australian Grand Prix before the Brit struck back in China.
Get Quotes on Home Insurance
Lewis Hamilton currently leads the F1 Drivers' World Championship
The Mercedes driver has on both occasions beaten his new team-mate Valtteri Bottas, who has finished third and sixth on his first two outings for the team.
But he is only in the seat because Nico Rosberg hung up his helmet just days after winning the 2016 world title.
“I was very surprised [when Rosberg retired],” Walker added.
This weekend's Bahrain Grand Prix will likely see one of the top two take the lead in the title race
“I think he is very bright though and he did the right thing.
“Rosberg went about it all very cleverly and scientifically and thoroughly and really deserves the world championship.
“Would he have won it again? Maybe yes, maybe no.
“But he doesn’t have to worry about it anymore.”
***Channel 4, the home of free-to-air Formula 1 with live coverage of ten Grand Prix this season and comprehensive highlights of every race. To watch the full interview 'F1 Meets… Murray Walker tune into C4 at 14:25 on Saturday 15th April.***