Southampton take a one goal lead going into the semi-final second leg on Wednesday night after Nathan Redmond gave them the edge in the tie.
Liverpool have registered just one win from their last six games and are struggling for confidence at the moment.
Philippe Coutinho has just returned to the squad while Joel Matip's six minutes against Swansea were his first since the draw with West Ham last month.
Jurgen Klopp admits there is a lack of positivity around Liverpool at the moment
Their title hopes are hanging by a thread after one league win in their last four and they face a Southampton side who will be buoyed by their 3-0 win over Leicester.
But Jurgen Klopp hopes the Liverpool crowd can get behind his side on Wednesday to help them get to Wembley.
“I think I have played more against Southampton than any other team," Klopp said.
Jurgen Klopp wants the Liverpool crowd to create a special atmosphere on Wednesday night
Liverpool fans clash on Twitter over Jurgen Klopp after Swansea defeat
Sun, January 22, 2017
Liverpool fans have clashed on Twitter over manager Jurgen Klopp after the Reds slipped to a 3-2 defeat against Swansea City yesterday
1 of 21
Get Quotes on Home Insurance
Liverpool fans clash over Jurgen Klopp and his tactics after the Reds slipped to a 3-2 defeat against Swansea
“They are a football playing side, against us they always defended pretty deep. I think that’s a sign of respect.
“In Southampton we knew it was not a good game for us. Probably both managers were frustrated. They had chances. It was only a 1-0, that is no different for us. Still everything is possible for us.
"I can feel it around us that it's not that positive anymore. But I know at Anfield on Wednesday night there will be wonderful atmosphere."