An increase of Iraqi military pressure has pushed back the terrorist group as they try to retain control of the city.
The Iraqi army has been targeting areas of the Tigris River which divides Iraq's third most-populated city.
In the footage an Iraqi UAV (Unmanned Aerial Vehicle) can be seen gliding above the target area before the attack is launched.
Isis troops can be seen gathering around several parked vehicles which were positioned on the western side of the river bank.
The Isis troops were fired at by the Iraqi army on the western Tigris River bank
Next the UAV fires off a missile which immediately explodes as it makes contact with a vehicle before black smoke rockets into the sky.
Isis terrorists can be seen fleeing the from Tigris River crossing as they get under cover after the blast from the Iraqi military.
The terrorist group are thought to use the Tigris to import weapons and supplies.
Advancing Iraqi forces claim to have liberated the eastern half of Mosul – with remaining Islamic State forces entrenched in the western section of the city.
Isis militants can be seen running away from the explosion moments after it went up in flames
Iraqi army fire a missile towards Isis militants as they recapture most of the eastern side of Mosul
Iraq began its attempts to take the city back around three months ago in a campaign that was backed by the US military.
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This attack now shows the Iraqi army beginning their siege on the western side of Mosul, which is still fully controlled by the terrorist group.
However, the Iraqi army is expecting another strong resistance from the jihadists who have a strong hold of the more populated west bank of the Tigris.
Civilians living in the area pose an issue for the Iraqi army as they risk being killed or wounded in the crossfire in the battle against the terrorist group.
Battle for Mosul
Tue, January 12, 2016
A major offensive to recapture Mosul from ISIS continues.
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Members of the Iraqi rapid response forces fire missile toward Islamic State militants during a battle between Iraqi forces and Islamic State militants in Somer district of eastern Mosul
The Iraqi army celebrate liberating the eastern side of Mosul
Commanding officer Lieutenant-General Talib Shaghati said the Counter Terrorism Services, had taken the eastern bank of the Tigris river.
Shaghati said: "Today we celebrate… the liberation of the eastern bank in Mosul."
Tens of thousands of residents have been displaced by the fighting in Mosul with several thousand civilians being killed or wounded in fighting since October.