Al Gore, who nearly became US President in 2000, has said that the causes of Brexit, and even the Syrian Civil War, could be traced to climate change.
The environmental activist revealed the bizarre claim during a speech to fans in London ahead of the release of his new environmental film An Inconvenient Sequel: Truth to Power.
Mr Gore, who was Vice President to Bill Clinton between 1992 and 2000, said the rising temperatures fueled the discontent the led to the Brexit referendum outcome.
He explained that extreme weather conditions were creating political instability "the world will find extremely difficult to deal with".
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Mr Gore told the audience at the Advertising Week Europe event in London that the "principal" cause of the Syrian Civil War had been the worst drought in 900 years, which forced 1.5 million people to move from the countryside to the cities.
He said that this created a "political powder keg situation" that Syrian government officials privately feared would explode into a war.
This then triggered a mass refugee wave into Europe, causing even greater political instability within the EU and helping convince UK voters to leave the Union last year.
The former presidential candidate said: "This collision between the power of industrial civilisation and the surprising fragility of the Earth’s ecosystem now poses a great danger that could even threaten the future of human civilisation itself.
"One of the lines of investigation scientists have been pursuing has led them to the conclusion that significant areas of the Middle East and North Africa are in danger of becoming uninhabitable.
"And, just a taste of this, to link it to some of the events that the UK and European Union are going through – think for a moment about what happened in Syria."
The former presidential candidate told an audience at the Advertising Week Europe event in London
This contributed in some ways to the desire of some in the UK to say ‘whoa, we’re not sure we want to be part of that anymore’
Mr Gore added: "Before the gates of hell opened in Syria, what happened was a climate-related extreme drought.
"From 2006 to 2010, 60 per cent of the farms in Syria were destroyed and 80 per cent of the livestock were killed.
"The drought in the eastern Mediterranean is the worst ever on record – the records only go back 900 years, but it’s historic.
“And 1.5 million climate refugees were driven into the cities in Syria, where they collided with refugees from the Iraq War.
“Wikileaks revealed the internal conversations in the Syrian government where they were saying to one another ‘we can’t handle this, there’s going to be a social explosion’.
"There are other causes of the Syrian civil war, but this was the principal one.
"This produced the incredible flow of refugees into Europe, which is creating political instability and which contributed in some ways to the desire of some in the UK to say ‘whoa, we’re not sure we want to be part of that anymore’".
He said that extreme weather conditions were creating political instability
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Mr Gore's alarming explanation comes just after current US Defence Secretary, General James Mattis, confirmed that the American military was taking climate change seriously.
He said: "Climate change is impacting stability in areas of the world where our troops are operating today.
"Climate change can be a driver of instability and the Department of Defence must pay attention to potential adverse impacts generated by this phenomenon.
"The effects of a changing climate – such as increased maritime access to the Arctic, rising sea levels, desertification, among others – impact our security situation."
Earlier this week, a study in the British Medical Journal also managed to link climate change to a growing diagnosis rate of diabetes.
The study read: "Diabetes incidence in the US and prevalence of glucose intolerance worldwide increase with higher outdoor temperature.
"A 1°C rise in environmental temperature would account for over 100 000 new diabetes cases per year in the USA alone, given a population of nearly 322 million people in 2015."